In the world of specialty chemicals, 2-Bromo-5-chloroaniline (CAS No. 823-57-4) plays a vital role as a highly valuable intermediate for the synthesis of pharmaceuticals, agrochemicals, and advanced organic compounds. Its dual halogen substitution makes it especially useful in targeted chemical transformations where precision and selectivity are required. This article explores its chemical profile, key applications, and its growing importance across modern industries.
Chemical Name: 2-Bromo-5-chloroaniline
CAS Number: 823-57-4
Molecular Formula: C₆H₅BrClN
Appearance: Typically appears as an off-white to light yellow crystalline solid
Molecular Weight: Approximately 208.47 g/mol
This compound consists of an aniline backbone with bromine and chlorine substituents positioned at the 2 and 5 locations of the aromatic ring. These substituents significantly influence its reactivity, making it suitable for advanced organic reactions such as substitution, coupling, and condensation reactions.
High Purity Compatibility: Ideal for high-precision synthesis
Stable Under Standard Conditions: Can be stored and transported with ease
Reactive Functional Groups: Facilitates further chemical modification
Selective Reactivity: Useful in designing complex molecular structures
Because of the combination of halogens and the amino group, 2-Bromo-5-chloroaniline acts as a versatile building block in multi-step synthesis.
One of the most prominent uses of 823-57-4 is in pharmaceutical compound development. It is used in:
Synthesis of active pharmaceutical ingredients (APIs)
Development of anti-inflammatory and anti-cancer agents
Production of heterocyclic compounds used in drug discovery
Its selective reactivity makes it a preferred choice for medicinal chemistry research.
2-Bromo-5-chloroaniline is extensively used in the production of:
Herbicides
Pesticides
Fungicides
Growth-regulating agents
These agrochemicals use halogenated intermediates to achieve strong efficacy and stability in various environmental conditions.
The compound serves as a precursor in the creation of specialty dyes and pigments. Its halogenated structure contributes to:
Enhanced color stability
Improved dye uptake
Increased resistance to UV and chemical exposure
This makes it valuable in textile, leather, and pigment manufacturing.
In organic chemistry labs and industrial synthesis, 2-Bromo-5-chloroaniline is used to create:
Complex aromatic compounds
Advanced intermediates
Specialty polymers
Custom molecules for R&D
It is especially useful in reactions that demand precise substitution on the aromatic ring.
The demand for 823-57-4 continues to rise due to its:
Versatility: Applicable across pharmaceuticals, agriculture, and specialty chemicals
Structural Value: Dual halogens enable unique synthetic pathways
Role in Innovation: Key component in new-generation chemical products
As industries increasingly shift toward more complex and high-performance molecules, chemicals like 2-Bromo-5-chloroaniline are expected to remain essential raw materials.
823-57-4 (2-Bromo-5-chloroaniline) is more than just a chemical intermediate—it is a cornerstone in the synthesis of numerous high-value products. Its stability, functional versatility, and wide applicability make it indispensable in pharmaceuticals, agrochemicals, dyes, and specialty chemical manufacturing. With increasing industrial focus on innovation and advanced chemistry, the importance of this compound will only continue to grow.
