CAS Number: 41202-77-1
Chemical Name: 1-(2,3-Dichlorophenyl)piperazine
IUPAC Name: 1-(2,3-Dichlorophenyl)piperazine
Synonyms:
2,3-Dichlorophenylpiperazine
1-(2,3-Dichlorobenzene)piperazine
DCPP (abbreviated form)
Molecular Formula: C₁₀H₁₂Cl₂N₂
Molecular Weight: ~231.12 g/mol
1-(2,3-Dichlorophenyl)piperazine consists of:
A piperazine ring (six-membered heterocycle containing two nitrogen atoms)
A 2,3-dichlorophenyl aromatic ring
Two chlorine substituents at the 2- and 3-positions
Secondary amine groups (–NH–)
Aromatic ring (phenyl group)
Aryl chloride substituents (–Cl)
Substituted piperazine derivative
Halogenated aromatic amine
Nitrogen-containing heterocyclic compound
Appearance: Off-white to pale yellow solid
Physical State: Solid (may also be supplied as a crystalline powder)
Melting Point: Typically reported between 70–100 °C (depending on purity)
Solubility:
Soluble in organic solvents such as methanol, ethanol, dichloromethane, and chloroform; limited solubility in water
Stability:
Stable under normal laboratory storage conditions; sensitive to strong oxidizing agents
The structure of 41202-77-1 offers significant synthetic flexibility due to:
The nucleophilic piperazine nitrogen atoms
Electron-withdrawing chlorine substituents on the aromatic ring
Aromatic substitution potential
Capability for salt formation
Alkylation and acylation of piperazine nitrogen
Nucleophilic aromatic substitution (under controlled conditions)
Formation of amide or urea derivatives
Synthesis of heterocyclic frameworks
Piperazine derivatives are widely used in medicinal chemistry.
1-(2,3-Dichlorophenyl)piperazine serves as:
A building block for CNS-active compounds
An intermediate in the synthesis of receptor-binding agents
A scaffold for structure–activity relationship (SAR) studies
The piperazine moiety is commonly found in:
Antidepressants
Antipsychotics
Antihistamines
Anxiolytic agents
Used in:
Heterocyclic compound development
Ligand design
Organic reaction optimization
Nitrogen-based functional material research
Its balanced hydrophilic-lipophilic nature makes it useful for studying molecular interaction behavior.
Industrial applications include:
Specialty intermediate production
Custom synthesis projects
Advanced chemical development programs
As with many halogenated amine compounds, appropriate safety measures should be followed.
May cause skin and eye irritation
Harmful if swallowed
May cause respiratory irritation
Use personal protective equipment (gloves, lab coat, safety glasses)
Handle in a well-ventilated area or fume hood
Avoid inhalation of dust or vapors
Store in tightly sealed containers
Store in a cool, dry place
Protect from moisture
Keep away from strong oxidizing agents
Maintain container tightly closed
Typical Purity Available: 97–99% (Research Grade)
41202-77-1 (1-(2,3-Dichlorophenyl)piperazine) is a halogenated piperazine derivative widely utilized in pharmaceutical research, heterocyclic synthesis, and fine chemical manufacturing. Its dual functionality—combining a reactive piperazine ring with a dichlorinated aromatic system—makes it a versatile and valuable intermediate in modern medicinal and synthetic chemistry.
As a trusted manufacturer and supplier in Hyderabad, SriniChem provides high-quality 41202-77-1 (1-(2,3-Dichlorophenyl)piperazine) produced under strict quality control standards. Our product, with CAS No: 41202-77-1, is suitable for both research and industrial use. Choose SriniChem for reliable supply, technical expertise, and customer-focused service. Contact SriniChem today for 1-(2,3-Dichlorophenyl)piperazine.
