Overview & Chemical Identity
CAS Number: 2924-15-4
Chemical Name: 2-Fluorophenylhydrazine hydrochloride
IUPAC Name: (2-Fluorophenyl)hydrazine hydrochloride
Synonyms:
o-Fluorophenylhydrazine hydrochloride;
2-Fluorobenzenhydrazide hydrochloride;
2-Fluoroaniline hydrazine hydrochloride (salt form)
Molecular Formula: C₆H₈ClFN₂
Molecular Weight: ~162.59 g/mol
Physical & Chemical Properties
Appearance: White to off-white crystalline powder
Physical State: Solid (hydrochloride salt)
Melting Point: Typically reported in the range of 170–185 °C (decomposition may occur; varies by purity)
Boiling Point: Not applicable (decomposes before boiling)
Solubility:
Freely soluble in water; soluble in methanol and ethanol; limited solubility in non-polar solvents
Stability:
Stable under recommended storage conditions; sensitive to air, light, and moisture; may oxidize upon prolonged exposure
Structural & Molecular Identifiers
Functional Groups:
Hydrazine group (–NH–NH₂)
Aromatic benzene ring
Fluoro substituent (–F)
Hydrochloride salt (protonated amine)
Chemical Class:
Aromatic hydrazine derivative / Fluorinated organic intermediate / Hydrazine salt
SMILES (representative):
FC1=CC=CC=C1NN.Cl
InChI Key (representative):
(Varies by database; available from chemical registries)
Functionality & Applications
Pharmaceutical & Agrochemical Intermediate
2924-15-4 is widely used as an intermediate in organic synthesis, particularly for:
Heterocycle formation
Pyrazole and indazole synthesis
Active pharmaceutical ingredient (API) development
Agrochemical compound synthesis
The hydrazine functionality enables condensation reactions with aldehydes, ketones, and β-dicarbonyl compounds.
Fine Chemical & Dye Synthesis
Used in:
Azo dye preparation
Specialty organic compounds
Fluorinated aromatic derivatives
Its ortho-fluoro substitution influences electronic properties and reactivity, making it useful in selective synthesis.
Research & Development
Commonly employed in:
Medicinal chemistry research
Structure–activity relationship (SAR) studies
Fluorinated compound development
Academic synthetic methodology research
The combination of hydrazine reactivity and fluorinated aromatic stability enhances its synthetic versatility.
Safety & Handling
GHS Classification (typical for hydrazine salts):
Harmful if swallowed
Toxic if inhaled
Causes skin and eye irritation
May cause respiratory irritation
May cause organ damage with prolonged exposure
Common Hazard Statements:
H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements:
P261: Avoid breathing dust or vapors
P280: Wear protective gloves, protective clothing, and eye protection
P305 + P351 + P338: IF IN EYES, rinse cautiously with water and remove contact lenses
P301 + P312: IF SWALLOWED, call a doctor if you feel unwell
Handle in a well-ventilated laboratory or industrial setting using appropriate personal protective equipment (PPE).
Practical Details & Supplier Information
Typical Purity: 97–99% (Research and Industrial Grade)
Storage Conditions:
Store in a tightly sealed container
Keep in a cool, dry, and well-ventilated area
Protect from light and moisture
Keep away from oxidizing agents and strong acids
Commercial Use:
Available from specialty chemical manufacturers for research, pharmaceutical intermediate synthesis, and industrial organic chemistry applications.
Not intended for direct pharmaceutical, food, or diagnostic use without proper regulatory compliance.
Summary Statement
2924-15-4 (2-Fluorophenylhydrazine Hydrochloride) is an important fluorinated aromatic hydrazine salt widely used as an intermediate in heterocycle synthesis, pharmaceutical development, and fine chemical manufacturing. Its reactive hydrazine functionality combined with fluorine substitution makes it a valuable building block in advanced organic synthesis and medicinal chemistry research.
