N-Benzylglycine Ethyl Ester (CAS 6436-90-4): Properties, Applications, and Industrial Importance

N-Benzylglycine Ethyl Ester, identified by the CAS number 6436-90-4, is a valuable organic compound widely used in pharmaceutical research, organic synthesis, and chemical manufacturing. Its unique structure and reactivity make it an essential building block for creating numerous intermediates and active compounds.

This article explores its properties, applications, benefits, and why the compound holds a significant place in modern chemical industries.


What is N-Benzylglycine Ethyl Ester (CAS 6436-90-4)?

N-Benzylglycine Ethyl Ester is an ester derivative of benzylglycine, featuring both amino acid and ester functionalities. This dual nature provides stability and reactivity, making it ideal for multi-step synthesis processes.

Key Chemical Details

  • Chemical Name: N-Benzylglycine Ethyl Ester

  • CAS Number: 6436-90-4

  • Molecular Formula: C11H15NO2

  • Molecular Weight: Approx. 193.24 g/mol

  • Appearance: Typically a colorless to pale yellow liquid or oil

  • Purity: Commonly available in high-purity forms for research and industrial requirements


Physical & Chemical Properties

N-Benzylglycine Ethyl Ester is known for:

  • Good solubility in organic solvents such as ethanol, methanol, dichloromethane, and acetone

  • High stability under room temperature conditions

  • Strong reactivity due to the presence of an ester group and benzyl functional group

These properties make it easy to handle and incorporate into synthetic procedures.


Applications of N-Benzylglycine Ethyl Ester (6436-90-4)

1. Pharmaceutical Intermediate

The compound is widely used in the synthesis of:

  • Active pharmaceutical ingredients (APIs)

  • Peptide-like molecules

  • Novel therapeutic compounds

Its ability to participate in nucleophilic substitution and condensation reactions makes it ideal for drug development processes.

2. Organic Synthesis

N-Benzylglycine Ethyl Ester acts as a flexible intermediate for:

  • Creating customized amino acid derivatives

  • Producing chiral compounds

  • Forming building blocks for advanced chemical structures

3. Research & Development

Chemical R&D laboratories utilize this compound for:

  • Reaction mechanism studies

  • Optimization of synthetic routes

  • Development of new chemical entities (NCEs)


Why Industries Prefer CAS 6436-90-4?

✔ High Purity Available

Manufacturers provide highly refined versions ideal for pharmaceutical-grade processes.

✔ Versatile Reactivity

Its ester and amino-acid-like structure allow multiple reaction pathways.

✔ Economical for Bulk Synthesis

Cost-effective for large-scale processes without compromising quality.


Storage & Handling Guidelines

  • Store in a cool, dry environment

  • Keep in a well-sealed container to avoid moisture absorption

  • Use proper PPE: gloves, goggles, lab coat

  • Handle in a well-ventilated area


Conclusion

N-Benzylglycine Ethyl Ester (CAS 6436-90-4) is a crucial chemical intermediate with broad applications in pharmaceuticals, organic synthesis, and research sectors. Its chemical versatility and stability make it a top choice for industries aiming to develop high-quality, complex compounds efficiently.

Whether you’re involved in drug development or advanced chemical manufacturing, this compound remains a trusted and valuable component in modern synthesis.