The compound identified by CAS Number 33721-54-9 (Acetamide,N-(2-methoxy-5-nitrophenyl)plays a crucial role in modern chemical research and industrial synthesis. Known for its stability and versatility, this compound is increasingly being used in pharmaceutical intermediates, organic synthesis, and biochemical research. As global demand for specialized chemical reagents continues to grow, CAS 33721-54-9 has emerged as a vital component in the research and manufacturing landscape.
CAS Number: 33721-54-9
Chemical Name: Acetamide,N-(2-methoxy-5-nitrophenyl)
Molecular Formula: C5H13NO2
Molecular Weight: 119.16 g/mol
Appearance: Clear, colorless liquid
Boiling Point: Approximately 90–95°C
Solubility: Miscible with most organic solvents
CAS 33721-54-9, commonly known as DMF-DMA, is an important chemical reagent used for introducing dimethylaminomethylene groups in organic molecules. It serves as a versatile intermediate for the synthesis of pharmaceuticals, agrochemicals, and fine chemicals.
Excellent reactivity in formylation and alkylation reactions
High purity and consistent performance for laboratory and industrial use
Functions as a methylating agent and condensation reagent
Compatible with a wide range of organic substrates
These properties make DMF-DMA an essential building block for researchers and chemical manufacturers worldwide.
Pharmaceutical Synthesis:
CAS 33721-54-9 is extensively used to produce active pharmaceutical ingredients (APIs), especially in the synthesis of heterocyclic compounds and intermediates used in antiviral, anticancer, and antibiotic drugs.
Agrochemical Production:
It serves as an intermediate in the manufacture of herbicides, fungicides, and insecticides, providing a foundation for crop protection products.
Organic and Fine Chemical Reactions:
DMF-DMA is a popular reagent in Vilsmeier–Haack reactions, formylations, and condensations, making it valuable in academic and industrial research.
Material Science:
Its chemical reactivity enables it to contribute to the development of functional materials and advanced polymers.
While CAS 33721-54-9 is a useful reagent, it must be handled with care:
Use gloves and eye protection to prevent contact.
Work in a well-ventilated area or fume hood.
Store in a cool, dry place, away from oxidizing agents and moisture.
Always refer to the Safety Data Sheet (SDS) for detailed hazard information.
The global demand for N,N-Dimethylformamide dimethyl acetal (CAS 33721-54-9) continues to increase in 2025 due to:
Expanding pharmaceutical R&D activities
Growth of specialty chemical production in Asia and Europe
Rising emphasis on green chemistry and efficient synthesis pathways
Major chemical manufacturers and distributors now provide research-grade and industrial-grade DMF-DMA with verified purity, ensuring consistency for both academic laboratories and large-scale production facilities.
CAS 33721-54-9 (Acetamide,N-(2-methoxy-5-nitrophenyl)) stands as a cornerstone reagent in modern organic chemistry. Its wide applicability, excellent reactivity, and stability make it indispensable for industries ranging from pharmaceuticals to materials science. As the global chemical sector evolves, the significance of DMF-DMA will continue to grow, offering researchers and manufacturers a reliable solution for innovative synthesis.
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