
Chemical Description:
IUPAC Name: 2-(Piperazin-1-yl)pyrimidine
Molecular Formula: C8H12N4
Molecular Weight: 164.21 g/mol
Structure: A heterocyclic organic compound consisting of a pyrimidine ring substituted at the 2-position with a piperazine moiety. The structure combines an aromatic diazine ring (pyrimidine) with a saturated six-membered piperazine ring containing two nitrogen atoms.
Chemical Classification:
Class: Heterocyclic amine; Pyrimidine derivative
Functional Groups:
Secondary amine (piperazine ring)
Aromatic heterocycle (pyrimidine ring)
Nitrogen-rich heterocyclic system
Applications & Usage:
Pharmaceutical research:
Commonly used as an intermediate in medicinal chemistry for the synthesis of bioactive molecules. The piperazine–pyrimidine framework is frequently found in compounds targeting central nervous system (CNS) receptors, kinase inhibitors, and antimicrobial agents.
Synthetic intermediate:
Widely employed as a building block in the development of drug candidates due to its versatile nitrogen atoms, which allow further functionalization and substitution reactions.
Storage & Handling:
Storage: Store in a cool, dry, well-ventilated place. Keep container tightly closed and protected from moisture.
Handling: Avoid contact with eyes, skin, and clothing. Use appropriate personal protective equipment. Handle in accordance with good industrial hygiene and safety practice.
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