Description:
2-Iodophenol is an organoiodine compound with the molecular formula C6H5IO. It consists of a phenol ring substituted with an iodine atom at the ortho (2-) position relative to the hydroxyl group. This pale yellow to light brown solid is moderately soluble in organic solvents and exhibits both nucleophilic and electrophilic reactivity due to the presence of the hydroxyl and iodine functional groups.
It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. The iodine atom serves as a useful handle for further functionalization via cross-coupling reactions such as Suzuki, Heck, or Sonogashira couplings.
Key Properties:
Molecular Formula: C6H5IO
Molecular Weight: 219.01 g/mol
Appearance: Pale yellow to brown solid
Boiling Point: ~218 °C (at reduced pressure)
Melting Point: 38–41 °C
Solubility: Soluble in organic solvents like ethanol, ether, and acetone
Safety and Handling:
2-Iodophenol should be handled with care in a well-ventilated area while wearing appropriate personal protective equipment (PPE). It can cause irritation to the skin, eyes, and respiratory tract. Avoid direct contact and inhalation of dust or vapors.
