In the specialty chemicals and advanced intermediates market, compounds like 53136-21-3 (Benzyl 4-Bromophenyl Sulfide) play a significant role in research, synthesis, and industrial applications. Known for its sulfur-containing structure and brominated aromatic ring, this compound is widely used as an intermediate in organic synthesis and pharmaceutical development.
This article explores the chemical profile, industrial applications, handling procedures, and safety measures associated with Benzyl 4-Bromophenyl Sulfide.
Chemical Name: Benzyl 4-Bromophenyl Sulfide
CAS Number: 53136-21-3
Molecular Formula: C13H11BrS
Molecular Weight: Approx. 279.19 g/mol
Chemical Structure: Contains a benzyl group linked to a 4-bromophenyl ring via a sulfur atom (thioether linkage).
The presence of a bromine atom on the aromatic ring enhances its reactivity in substitution reactions, while the sulfur atom provides unique chemical behavior valuable in synthetic transformations.
Benzyl 4-Bromophenyl Sulfide is commonly used as a building block in the synthesis of pharmaceutical compounds. The brominated aromatic structure allows for:
Cross-coupling reactions
Functional group substitutions
Formation of complex drug molecules
Sulfur-containing intermediates are often crucial in medicinal chemistry, especially in the development of antimicrobial, anti-inflammatory, and specialty therapeutic agents.
In agrochemical manufacturing, brominated sulfides are used as intermediates in the production of:
Crop protection chemicals
Fungicides
Herbicide precursors
The compound’s structural stability and reactivity make it suitable for further derivatization.
53136-21-3 is also used in specialty chemical manufacturing where sulfur-based aromatic compounds are required. Applications include:
Advanced material synthesis
Performance additives
Chemical research reagents
Academic and industrial laboratories utilize Benzyl 4-Bromophenyl Sulfide for:
Reaction mechanism studies
Organic synthesis method development
Catalysis research
Its predictable reactivity makes it valuable for experimental chemistry.
The compound exhibits properties typical of:
Aromatic bromides – Suitable for palladium-catalyzed coupling reactions (e.g., Suzuki, Heck reactions).
Thioethers (Sulfides) – Can undergo oxidation to sulfoxides or sulfones.
These characteristics make it a flexible intermediate in multi-step synthetic processes.
Like many brominated and sulfur-containing organic compounds, 53136-21-3 must be handled with care.
May cause skin and eye irritation
Potential respiratory irritation if inhaled
Harmful if swallowed
Environmental hazard if released improperly
Always consult the official Safety Data Sheet (SDS) before handling.
When working with Benzyl 4-Bromophenyl Sulfide, use:
Protective gloves (nitrile recommended)
Safety goggles
Lab coat
Proper respiratory protection if required
Chemical-resistant apron in bulk handling
Store in a cool, dry, well-ventilated area
Keep away from heat, sparks, and open flames
Protect from direct sunlight
Store in tightly sealed containers
In Case of Spill:
Avoid breathing vapors
Use inert absorbent material
Dispose of waste in accordance with local regulations
Disposal:
Follow hazardous chemical disposal regulations
Do not release into drains or the environment
Manufacturers and suppliers must comply with:
Local chemical safety regulations
Transportation guidelines (ADR, IMDG, IATA if applicable)
Environmental protection laws
Proper labeling and documentation are essential for international trade.
For industrial buyers, key quality parameters include:
Purity percentage
Moisture content
Melting point consistency
Residual solvent levels
Reliable suppliers provide:
Certificate of Analysis (COA)
Safety Data Sheet (SDS)
Batch traceability documentation
53136-21-3 (Benzyl 4-Bromophenyl Sulfide) is a versatile chemical intermediate widely used in pharmaceutical synthesis, agrochemical development, and specialty chemical manufacturing. Its brominated aromatic structure and sulfur linkage offer significant flexibility in organic reactions, making it a valuable compound for research and industrial production.
