4-Chloro-4′-fluorobutyrophenone, registered under CAS number 3874-54-2, is an important organic intermediate widely used in pharmaceutical synthesis, fine chemical manufacturing, and research laboratories. Due to the presence of chloro, fluoro, and ketone functionalities, the compound offers excellent reactivity, making it valuable for creating more complex chemical structures.
This article provides a complete overview of its chemical profile, properties, applications, and industrial significance.
4-Chloro-4′-fluorobutyrophenone is a halogenated aromatic ketone featuring both chlorine and fluorine substituents. These groups enhance the compound’s electrophilic properties, making it useful for forming a variety of pharmaceutical intermediates.
Chemical Name: 4-Chloro-4′-fluorobutyrophenone
CAS Number: 3874-54-2
Molecular Formula: C₁₀H₁₀ClFO
Molecular Weight: Approximately 200.63 g/mol
Appearance: Pale to yellow liquid or solid (depending on purity and storage conditions)
4-Chloro-4′-fluorobutyrophenone is characterized by:
Good solubility in organic solvents such as ethanol, methanol, chloroform, and dichloromethane
High stability, making it suitable for long-term research use
Reactivity driven by the carbonyl group, allowing participation in condensation and substitution reactions
Electrophilic aromatic substitution compatibility due to halogen substituents
These properties make it a preferred intermediate in multistep organic synthesis.
This compound is widely used in the preparation of:
Drug candidates
Active pharmaceutical ingredients
Halogenated aromatic derivatives
Precursors in medicinal chemistry
Its functional groups provide pathways for structural modifications and bioactivity optimization.
4-Chloro-4′-fluorobutyrophenone is ideal for producing:
Specialty chemicals
Advanced intermediates
Custom molecules for chemical industries
Used extensively in:
Reaction mechanism studies
Optimization of synthetic pathways
Development of halogenated derivatives for R&D projects
Researchers value its predictable reactivity and versatility.
Due to its halogenated structure, it is often utilized in synthesizing:
Herbicide precursors
Pesticide intermediates
Bioactive aromatic compounds
The combination of chlorine, fluorine, and ketone groups broadens synthetic applications.
Suitable for storage and transportation under standard laboratory conditions.
Allows efficient production of complex organic molecules.
Ideal for multi-step preparation in pharmaceutical and chemical industries.
Store in a cool, dry, and well-ventilated area.
Keep away from strong oxidizing agents.
Use proper PPE: gloves, goggles, and lab coat.
Avoid inhalation or prolonged skin contact.
4-Chloro-4′-fluorobutyrophenone (CAS 3874-54-2) is a highly valuable intermediate in the fields of pharmaceutical synthesis, fine chemical manufacturing, and research chemistry. Its halogenated structure and reactive ketone group make it indispensable for creating advanced organic molecules with precision and efficiency.
