3680-69-1 (4-Chloro-7H-pyrrolo[2,3-d]pyrimidine): A Key Building Block in Modern Pharmaceutical Synthesis

In the world of medicinal chemistry, heterocyclic compounds form the backbone of many groundbreaking drugs. One such valuable intermediate is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, identified by the CAS number 3680-69-1. This compound is widely used as a starting material for creating advanced pharmaceutical molecules, especially kinase inhibitors and antiviral agents.

This blog highlights its structure, properties, applications, and importance in chemical research.

What is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 3680-69-1)?

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic aromatic compound belonging to the pyrrolopyrimidine chemical family. Compounds in this class serve as vital intermediates for designing biologically active molecules due to their ability to interact with enzyme binding sites and biological receptors.

With a chlorine atom at the 4-position, this compound provides high reactivity, making it suitable for substitution reactions that yield diverse functional derivatives.

Chemical Information

Key Properties

• High chemical reactivity due to the chloro substituent

• Versatile intermediate for nucleophilic substitution

• Excellent stability under normal storage conditions

• Ideal scaffold for drug-design chemistry

Major Applications of 3680-69-1

1. Pharmaceutical Intermediate

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is widely used in the synthesis of:

• Kinase inhibitors

• Antiviral compounds

• Anti-inflammatory agents

• Cancer therapeutics

Its heterocyclic structure is ideal for forming small-molecule inhibitors that target specific biological pathways.

2. Organic Synthesis

Its chlorine-substituted ring acts as an excellent electrophile, making it suitable for:

• Substitution reactions

• Coupling reactions

• Formation of more complex heterocycles

3. Research in Medicinal Chemistry

This compound is a preferred choice for R&D teams exploring new therapeutic candidates. Its molecular framework allows easy modification to tune biological activity.

4. Development of Bioactive Molecules

It contributes to the creation of molecules with:

• Enhanced potency

• Improved pharmacokinetics

• Better selectivity for target enzymes

Storage & Handling

To maintain stability:

• Store in a cool, dry place

• Keep in tightly sealed containers

• Avoid exposure to moisture

• Handle using gloves, protective eyewear, and lab coat

Why Researchers Choose 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

• Reliable intermediate for medicinal chemistry

• High reactivity for synthetic versatility

• Stable and easy to store

• Widely available at high purity

Its combination of reactivity and structural importance makes it a staple in pharmaceutical discovery programs.

Conclusion

3680-69-1 (4-Chloro-7H-pyrrolo[2,3-d]pyrimidine) is an essential building block in the synthesis of cutting-edge therapeutic compounds. Its unique heterocyclic structure, reactivity, and broad application potential make it an indispensable reagent for researchers working on drug design, molecular development, and advanced organic synthesis.