In the world of pharmaceutical intermediates and fine chemicals, 2,4-Dichloropyrimidine (CAS Number: 3934-20-1) stands out as a highly valuable compound. Its unique chemical structure and reactivity make it essential in the synthesis of advanced molecules, especially in the pharmaceutical, agrochemical, and biotechnology industries.
This article explores its chemical properties, applications, handling guidelines, and why it is a preferred building block for modern chemical manufacturing.
2,4-Dichloropyrimidine is a halogenated heterocyclic compound derived from pyrimidine, a six-membered aromatic ring containing two nitrogen atoms.
The presence of two chlorine atoms at positions 2 and 4 enhances its electrophilic properties, making it highly useful for substitution reactions.
CAS Number: 3934-20-1
Molecular Formula: C₄H₂Cl₂N₂
Molecular Weight: 164.98 g/mol
Appearance: White to off-white crystalline solid
Purity: Typically > 98% for industrial use
2,4-Dichloropyrimidine is known for its high reactivity with nucleophiles. This chemical behavior enables selective substitution, which is crucial in synthesizing complex organic molecules.
Electrophilic nature due to electron-withdrawing chlorine atoms
Solubility: Soluble in organic solvents like ethanol, dichloromethane, and DMF
Reactivity: Undergoes nucleophilic aromatic substitution (SNAr)
This reactivity enables the replacement of one or both chlorine atoms with various functional groups, making it a versatile intermediate.
2,4-Dichloropyrimidine is widely used in synthesizing:
Antiviral compounds
Anticancer drugs
Anti-inflammatory molecules
CNS-active agents
Many modern APIs (Active Pharmaceutical Ingredients) use pyrimidine-based scaffolds, making this chemical a valuable building block.
It serves as a key intermediate for developing:
Herbicides
Fungicides
Insecticides
Its ability to form highly active pyrimidine derivatives makes it essential in crop protection chemical design.
Researchers and chemical manufacturers use it for:
Heterocyclic chemical modifications
Designing novel molecules
Creating intermediates for material science applications
Laboratories often use 2,4-Dichloropyrimidine for:
Structure–activity relationship (SAR) studies
Synthesis of nucleoside analogues
Medicinal chemistry research
Being a reactive halogenated compound, proper handling is essential.
Use gloves, lab coat, and safety goggles
Work in a well-ventilated area or fume hood
Avoid inhalation, ingestion, and skin contact
Keep in tightly sealed containers
Store in a cool, dry place
Keep away from heat sources and moisture
Here are the top reasons this compound is in high demand:
Its broad application range makes it an important raw material in modern chemistry-driven industries.
2,4-Dichloropyrimidine (CAS 3934-20-1) is an essential intermediate recognized for its exceptional reactivity and widespread use in pharmaceuticals, agrochemicals, and advanced organic synthesis. Whether in industrial manufacturing or research environments, it remains a cornerstone compound that helps create innovative and effective chemical products.
