2,4-Dichloropyrimidine, a halogenated pyrimidine derivative, has gained importance in the pharmaceutical and agrochemical industries due to its reactivity and role as an intermediate in organic synthesis. In this article, we explore the essential properties, applications, and safety considerations of 2,4-Dichloropyrimidine (CAS No. 3934-20-1).
Chemical Name: 2,4-Dichloropyrimidine
CAS Number: 3934-20-1
Molecular Formula: C4H2Cl2N2
Molecular Weight: 149.98 g/mol
Synonyms: Pyrimidine, 2,4-dichloro-; 2,4-Dichloro-1,3-diazine
2,4-Dichloropyrimidine features a six-membered aromatic ring containing two nitrogen atoms at positions 1 and 3, with chlorine atoms substituted at positions 2 and 4.
Appearance: White to off-white crystalline solid
Melting Point: 36–38 °C
Boiling Point: ~207 °C
Solubility: Soluble in common organic solvents such as ethanol, ether, and chloroform; slightly soluble in water
Density: ~1.45 g/cm³
Reactivity: The chlorine atoms in positions 2 and 4 are reactive toward nucleophilic substitution, making this compound a valuable intermediate.
2,4-Dichloropyrimidine is a versatile building block in the synthesis of a wide range of pharmaceutical agents, particularly in antiviral, anticancer, and antibacterial drug development.
Used to synthesize kinase inhibitors
Found in some tyrosine kinase receptor antagonists
Precursor for drugs acting on the central nervous system
It is also employed in the production of herbicides, fungicides, and insecticides.
Intermediate for pyrimidine-based agrochemicals
Enables synthesis of systemic and contact-based crop protection agents
Researchers use this compound in designing new heterocyclic compounds due to its reactive dichloro-substitution, facilitating functionalization at specific positions.
Suitable for creating libraries of substituted pyrimidines in medicinal chemistry
Valuable for click chemistry and combinatorial chemistry
Like many halogenated aromatic compounds, 2,4-Dichloropyrimidine should be handled with care. The following are general safety guidelines:
Irritant: May cause skin, eye, and respiratory irritation
Toxicity: Avoid ingestion, inhalation, or prolonged skin contact
Combustibility: Combustible; avoid exposure to flame or high heat
Wear safety goggles, gloves, and protective clothing
Use in a well-ventilated fume hood
Avoid generating dust or aerosol
Store in a cool, dry, well-ventilated place
Keep container tightly closed
Protect from light and incompatible materials like strong oxidizers
Inhalation: Move to fresh air, seek medical attention if symptoms persist
Skin contact: Wash with soap and water
Eye contact: Rinse with plenty of water, get medical advice
Ingestion: Do not induce vomiting; consult a poison control center
2,4-Dichloropyrimidine is not highly water-soluble, but care must be taken to prevent its release into the environment. Proper waste disposal according to local regulations is essential.
2,4-Dichloropyrimidine (CAS 3934-20-1) plays a critical role in modern chemical synthesis, especially in pharmaceuticals and agrochemicals. Due to its chemical reactivity and utility in producing high-value bioactive molecules, it remains a popular choice among chemists. However, safe handling and storage practices must be strictly followed to ensure environmental and personal safety.
