CAS Number: 22009-37-6
Chemical Name: 7-Methyl-1-tetralone
IUPAC Name: 7-Methyl-3,4-dihydro-2H-naphthalen-1-one
Synonyms:
7-Methyl-1,2,3,4-tetrahydronaphthalen-1-one;
7-Methyl-α-tetralone;
7-Methyl-3,4-dihydro-1(2H)-naphthalenone
Molecular Formula: C₁₁H₁₂O
Molecular Weight: ~160.21 g/mol
Appearance: Colorless to pale yellow liquid or crystalline solid (depending on temperature and purity)
Physical State: Liquid or low-melting solid
Melting Point: Typically 25–35 °C (may vary depending on purity)
Boiling Point: Approximately 260–270 °C
Solubility:
Soluble in common organic solvents such as ethanol, methanol, ether, chloroform, and dichloromethane;
Practically insoluble in water
Stability:
Stable under normal laboratory conditions;
Sensitive to strong oxidizing agents and prolonged exposure to air and light
Functional Groups:
Ketone group (–C=O)
Aromatic benzene ring
Saturated cyclohexyl ring (tetralone structure)
Methyl substituent (–CH₃)
Chemical Class:
Aromatic ketone / Tetralone derivative
SMILES (representative):
CC1=CC2=C(C=C1)CCC(=O)C2
InChI Key (representative):
(Varies by database; available from chemical registries)
22009-37-6 is widely used as a versatile intermediate in organic synthesis, particularly in:
Pharmaceutical intermediate preparation
Fine chemical manufacturing
Functional material development
Fragrance and specialty compound synthesis
The ketone functionality enables diverse chemical transformations including reduction, oxidation, condensation, and alkylation reactions.
Intermediate in the synthesis of bioactive molecules
Building block for heterocyclic compounds
Precursor for substituted naphthalene derivatives
Used in structure–activity relationship (SAR) studies
Its rigid bicyclic structure makes it valuable in designing compounds with defined stereochemistry and biological activity.
Commonly employed in:
Academic organic chemistry laboratories
Medicinal chemistry research programs
Development of novel catalytic transformations
Advanced material precursor research
The presence of both an aromatic system and a reactive ketone group enhances its synthetic versatility.
GHS Classification (typical for similar ketone compounds):
Harmful if swallowed
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Common Hazard Statements:
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements:
P261: Avoid breathing vapors
P280: Wear protective gloves and eye protection
P305 + P351 + P338: IF IN EYES, rinse cautiously with water and remove contact lenses
P301 + P312: IF SWALLOWED, call a doctor if you feel unwell
Handle in a well-ventilated area using appropriate personal protective equipment (PPE).
Typical Purity: 97–99% (Research and Industrial Grade)
Storage Conditions:
Store in a tightly sealed container
Keep in a cool, dry, and well-ventilated area
Protect from light and moisture
Keep away from strong oxidizing agents
Commercial Use:
Available from specialty chemical manufacturers for research and industrial organic synthesis applications.
Not intended for direct pharmaceutical, food, or diagnostic use without proper regulatory compliance.
22009-37-6 (7-Methyl-1-tetralone) is an important aromatic ketone widely used as a synthetic intermediate in pharmaceutical, fine chemical, and research applications. Its tetralone core structure combined with a reactive ketone group makes it a versatile building block for carbon–carbon bond formation, heterocycle synthesis, and advanced organic transformations.
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