5-Bromo-2-chlorobenzoic acid (CAS No. 21739-92-4) is a halogen-substituted aromatic carboxylic acid widely used as a key intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. The presence of both bromine and chlorine substituents on the benzene ring enhances its chemical reactivity, making it valuable for advanced organic transformations.
This article provides a detailed overview of 21739-92-4 (5-Bromo-2-chlorobenzoic acid), including its chemical properties, industrial applications, and essential safety considerations.
Chemical Name: 5-Bromo-2-chlorobenzoic acid
CAS Number: 21739-92-4
Molecular Formula: C₇H₄BrClO₂
Molecular Weight: ~235.46 g/mol
IUPAC Name: 5-Bromo-2-chlorobenzoic acid
Chemical Class: Halogenated aromatic carboxylic acid
Benzene ring substituted with:
Carboxylic acid (-COOH) functional group
Bromine (Br) at the 5-position
Chlorine (Cl) at the 2-position
This substitution pattern makes the compound highly suitable for cross-coupling reactions and functional group modifications.
Property |
Description |
|---|---|
Appearance |
White to off-white crystalline powder |
Odor |
Odorless or faint |
Solubility |
Slightly soluble in water; soluble in organic solvents |
Melting Point |
Moderate to high |
Stability |
Stable under recommended storage conditions |
Weak organic acid behavior
Excellent reactivity in Suzuki, Heck, and nucleophilic substitution reactions
Suitable for halogen exchange and derivatization
Intermediate in the synthesis of active pharmaceutical ingredients (APIs)
Used in the development of anti-inflammatory, antimicrobial, and oncology-related compounds
Valuable building block in medicinal chemistry research
Used in the synthesis of herbicides, fungicides, and pesticide intermediates
Supports development of high-efficiency crop protection products
Precursor for custom organic synthesis
Used in dye, pigment, and specialty material manufacturing
Suitable for scale-up chemical production
Commonly used in organic synthesis laboratories
Ideal for reaction pathway optimization and chemical innovation
5-Bromo-2-chlorobenzoic acid is typically produced through:
Halogenation of benzoic acid derivatives
Controlled aromatic substitution reactions
Purification using crystallization or filtration methods
High-purity grades are supplied to meet industrial and research-grade requirements.
May cause skin and eye irritation
Harmful if swallowed or inhaled in large quantities
Dust may cause respiratory discomfort
Use appropriate personal protective equipment (PPE)
Handle in well-ventilated areas
Avoid direct contact with skin and eyes
Store in a cool, dry, and well-ventilated place
Keep container tightly sealed
Protect from moisture and direct sunlight
Dispose according to local environmental regulations
Avoid release into soil and water systems
Review Safety Data Sheet (SDS) before use
The compound is generally supplied in compliance with international chemical transport and safety standards.
Typical purity: ≥98%
Supplied with Certificate of Analysis (COA)
Secure packaging to ensure stability during transportation
21739-92-4 (5-Bromo-2-chlorobenzoic acid) is an essential halogenated aromatic intermediate used across pharmaceutical, agrochemical, and specialty chemical industries. Its well-defined chemical properties and broad applicability make it a reliable choice for manufacturers and researchers.
