2-(1-Piperazinyl)pyrimidine, identified by the CAS number 20980-22-7, is an important heterocyclic compound widely used as an intermediate in pharmaceuticals, specialty chemicals, and research chemistry. Its structure combines a pyrimidine ring with a piperazine unit, giving it unique reactivity and making it a preferred building block for advanced organic synthesis.
In this article, we explore the properties, applications, and significance of 20980-22-7 (2-(1-Piperazinyl)pyrimidine) across various scientific and industrial sectors.
2-(1-Piperazinyl)pyrimidine is a nitrogen-rich heterocyclic compound, combining two widely used chemical motifs:
Pyrimidine ring – a key structure found in nucleic acids, pharmaceuticals, and bioactive molecules
Piperazine ring – a common fragment in medicinal chemistry used to improve solubility and biological activity
Chemical Name: 2-(1-Piperazinyl)pyrimidine
CAS Number: 20980-22-7
Molecular Formula: C8H12N4
Category: Heterocyclic organic intermediate / Pharmaceutical intermediate
The combination of these two rings makes this compound highly versatile for research and chemical development.
The compound contains multiple nitrogen atoms, enabling diverse chemical interactions and making it valuable for complex molecular design.
Its structural composition enhances solubility in organic media and supports reactions required in medicinal and fine chemical synthesis.
It serves as a scaffold for creating molecules with improved biological compatibility, stability, and activity.
This compound is widely used in the development of:
API intermediates
Experimental drug candidates
Bioactive heterocycles
Medicinal chemists use it to modify molecular structures for better therapeutic performance.
Because of its dual-ring structure, it is commonly used in studies related to:
Molecular docking
SAR (structure–activity relationship) research
Drug design and screening
Its nitrogen-rich framework often enhances target-binding potential.
2-(1-Piperazinyl)pyrimidine serves as a precursor in synthesizing complex organic materials such as:
Specialty intermediates
Functionalized heterocycles
Custom research compounds
Its versatile reactivity makes it a preferred starting material in organic chemistry labs.
Researchers utilize the compound for:
Developing new heterocyclic scaffolds
Exploring reaction mechanisms
Building libraries of small molecules
Its multi-functional nature provides excellent value for scientific studies.
Although widely used, proper chemical safety precautions should always be followed.
Gloves
Lab coat
Safety goggles
Adequate ventilation
Store in a cool, dry, well-ventilated area
Keep container tightly sealed
Avoid exposure to heat and moisture
Avoid inhalation or direct contact
Follow SDS guidelines provided by suppliers
Use proper laboratory handling procedures
This compound plays a key role across multiple industries due to its:
Versatility
Nitrogen-rich heterocyclic structure
Value in drug discovery and fine chemical synthesis
From pharmaceuticals to research organizations, 2-(1-Piperazinyl)pyrimidine continues to be a fundamental intermediate for innovation and development.
20980-22-7 (2-(1-Piperazinyl)pyrimidine) is a highly valuable compound that supports advancements in medicinal chemistry, organic synthesis, and chemical research. Its heterocyclic structure and versatile reactivity make it an essential intermediate for industries working on modern drug development and high-performance organic compounds.
