20980-22-7 (2-(1-Piperazinyl)pyrimidine) is an important heterocyclic organic compound widely used in pharmaceutical and chemical research. Due to its pyrimidine core and piperazine moiety, this compound is highly valued as an intermediate in the synthesis of biologically active molecules. This article highlights its properties, applications, and overall chemical importance.
2-(1-Piperazinyl)pyrimidine consists of a pyrimidine ring substituted with a piperazine group, resulting in a structure commonly found in medicinal chemistry. Such frameworks are frequently used in drug discovery because of their favorable biological and physicochemical properties.
Chemical Name: 2-(1-Piperazinyl)pyrimidine
CAS Number: 20980-22-7
Molecular Formula: C₈H₁₂N₄
Molecular Weight: Approximately 164.21 g/mol
The compound exhibits several characteristics that make it suitable for advanced synthesis:
Typically appears as a solid under standard conditions
High nitrogen content contributes to basicity
Good solubility in water and polar organic solvents
Capable of forming salts to enhance stability and bioavailability
Chemically stable under normal laboratory conditions
These properties support its widespread use in research and manufacturing environments.
This compound finds application across multiple domains:
Pharmaceutical Research and Drug Discovery
It serves as a key intermediate in the development of therapeutic agents, particularly in antimicrobial, antiviral, and oncology-related research.
Medicinal Chemistry Studies
The pyrimidine–piperazine framework is commonly explored for structure–activity relationship (SAR) studies.
Specialty Chemical Synthesis
Used as a building block for synthesizing complex nitrogen-containing molecules.
Academic and Industrial Research
Frequently utilized in laboratories for chemical and biological evaluation studies.
The chemical importance of 20980-22-7 (2-(1-Piperazinyl)pyrimidine) lies in its versatility as a heterocyclic scaffold. The combination of a pyrimidine ring and piperazine unit allows chemists to design compounds with enhanced binding affinity, selectivity, and pharmacokinetic properties, making it a valuable component in modern medicinal chemistry.
Standard laboratory safety measures should be followed when handling this compound:
Use appropriate personal protective equipment (PPE)
Avoid inhalation and direct contact
Store in tightly closed containers in a dry, well-ventilated area
Adhering to recommended safety practices ensures safe and effective use.
20980-22-7 (2-(1-Piperazinyl)pyrimidine) is a chemically and biologically significant compound with broad applications in pharmaceutical research and specialty chemical synthesis. Its structural versatility and favorable properties make it an essential intermediate in the development of next-generation therapeutic molecules.
