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156-83-2 (4-Chloro-2,6-diaminopyrimidine)

156-83-2 (4-Chloro-2,6-diaminopyrimidine) Manufacturers in Hyderabad, India

Overview & Chemical Identity

CAS Number: 156-83-2

Chemical Name: 4-Chloro-2,6-diaminopyrimidine

IUPAC Name: 4-Chloropyrimidine-2,6-diamine

Synonyms:
4-Chloro-2,6-pyrimidinediamine;
2,6-Diamino-4-chloropyrimidine;
4-Chloro-2,6-diaminopyrimidine base

Molecular Formula: C₄H₅ClN₄

Molecular Weight: ~144.56 g/mol

Physical & Chemical Properties

Appearance: White to off-white crystalline powder

Physical State: Solid

Melting Point: Approximately 210–220 °C (may vary depending on purity)

Boiling Point: Decomposes before boiling

Solubility:
Slightly soluble in water; soluble in polar organic solvents such as methanol, ethanol, and DMSO

Stability:
Stable under standard laboratory conditions; sensitive to strong oxidizing agents and prolonged exposure to moisture

Structural & Molecular Identifiers

Functional Groups:

  • Chlorine substituent (–Cl)

  • Two amino groups (–NH₂)

  • Pyrimidine heterocyclic ring

Chemical Class:

Chlorinated heterocycle / Diaminopyrimidine derivative

SMILES (representative):
NC1=NC(Cl)=NC(N)=N1

InChI Key (representative):
(Varies by database; available from chemical registries)

Functionality & Applications

Heterocyclic Intermediate

156-83-2 is an important intermediate in heterocyclic chemistry. The pyrimidine ring substituted with amino and chloro groups allows selective substitution reactions and further functionalization, including:

  • Nucleophilic aromatic substitution (SNAr)

  • Cross-coupling reactions

  • Formation of substituted pyrimidines

  • Multi-step heterocycle synthesis

The chlorine atom at the 4-position provides a reactive site for synthetic modification.

Pharmaceutical Applications

4-Chloro-2,6-diaminopyrimidine is widely used in:

  • Synthesis of pharmaceutical intermediates

  • Development of antifolate and anticancer agents

  • Preparation of antiviral and antimicrobial compounds

  • Medicinal chemistry research programs

Diaminopyrimidine derivatives are key structural components in various bioactive molecules due to their interaction with biological enzymes and receptors.

Agrochemical & Fine Chemical Synthesis

Used in the manufacture of:

  • Crop protection agents

  • Nitrogen-containing specialty chemicals

  • Advanced fine chemical intermediates

Its nitrogen-rich heterocyclic structure makes it valuable for producing compounds with enhanced biological activity.

Research & Development

Commonly employed in:

  • Academic organic synthesis research

  • Medicinal chemistry development

  • Structure–activity relationship (SAR) studies

  • Enzyme inhibition research

  • Development of novel heterocyclic frameworks

The presence of two amino groups increases hydrogen bonding potential, enhancing its utility in drug design studies.

Safety & Handling

GHS Classification (typical for similar diamino heterocycles):

  • Harmful if swallowed

  • Causes skin irritation

  • Causes serious eye irritation

  • May cause respiratory irritation

Common Hazard Statements:

  • H302: Harmful if swallowed

  • H315: Causes skin irritation

  • H319: Causes serious eye irritation

  • H335: May cause respiratory irritation

Precautionary Statements:

  • P261: Avoid breathing dust

  • P280: Wear protective gloves and eye protection

  • P305 + P351 + P338: IF IN EYES, rinse cautiously with water

  • P301 + P312: IF SWALLOWED, call a doctor if you feel unwell

Handle in a well-ventilated laboratory using appropriate personal protective equipment (PPE).

Practical Details & Supplier Information

Typical Purity: 97–99% (Research and Industrial Grade)

Storage Conditions:

  • Store in a tightly sealed container

  • Keep in a cool, dry, and well-ventilated area

  • Protect from moisture and direct sunlight

  • Keep away from strong oxidizing agents

Commercial Use:
Available from specialty chemical manufacturers for research, pharmaceutical intermediate production, and industrial organic synthesis applications.
Not intended for direct pharmaceutical, food, or diagnostic use without proper regulatory compliance.

Summary Statement

156-83-2 (4-CHLORO-2,6-DIAMINOPYRIMIDINE) is a valuable chlorinated diaminopyrimidine compound widely utilized as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its reactive chloro group and nitrogen-rich pyrimidine structure provide excellent versatility in heterocyclic chemistry, making it an essential building block for advanced research and industrial applications.

As a trusted manufacturer and supplier in Hyderabad, SriniChem provides high-quality 156-83-2 (4-CHLORO-2,6-DIAMINOPYRIMIDINE) produced under strict quality control standards. Our product, with CAS No: 156-83-2, is suitable for both research and industrial use. Choose SriniChem for reliable supply, technical expertise, and customer-focused service. Contact SriniChem today for 4-CHLORO-2,6-DIAMINOPYRIMIDINE.

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