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14906-37-7 (Ethyl isonicotinate N-oxide)

14906-37-7 (Ethyl isonicotinate N-oxide) Manufacturers in Hyderabad, India

Overview & Chemical Identity

CAS Number: 14906-37-7

Chemical Name: Ethyl isonicotinate N-oxide

IUPAC Name: Ethyl 4-(oxidopyridin-1-ium-1-yl)carboxylate

Synonyms:
Ethyl 4-pyridinecarboxylate N-oxide;
Isonicotinic acid ethyl ester N-oxide;
4-Ethoxycarbonylpyridine N-oxide;
Ethyl isonicotinate 1-oxide

Molecular Formula: C₈H₉NO₃

Molecular Weight: ~167.16 g/mol

Physical & Chemical Properties

Appearance: White to off-white crystalline powder

Physical State: Solid

Melting Point: Typically reported in the range of 60–70 °C (may vary depending on purity)

Boiling Point: Not typically reported; decomposes at elevated temperatures

Solubility:
Soluble in polar organic solvents such as methanol, ethanol, acetone, acetonitrile, and DMSO; moderately soluble in water

Stability:
Stable under standard laboratory conditions; may be sensitive to strong reducing agents and prolonged exposure to moisture

Structural & Molecular Identifiers

Functional Groups:

  • Pyridine N-oxide group (–N⁺→O⁻)

  • Ester group (–COOEt)

  • Aromatic heterocyclic ring

Chemical Class:
Pyridine N-oxide derivative / Heterocyclic aromatic ester

SMILES (representative):
CCOC(=O)C1=CC=N+C=C1

InChI Key (representative):
(Varies by database; available from chemical registries)

Functionality & Applications

Synthetic Intermediate

14906-37-7 is widely used as an intermediate in organic synthesis, particularly in the preparation of substituted pyridine derivatives.

Its N-oxide functionality enhances reactivity and allows:

  • Electrophilic substitution reactions

  • Regioselective functionalization of pyridine rings

  • Activation for nucleophilic aromatic substitution

The N-oxide group can be reduced back to the corresponding pyridine after functional modification.

Pharmaceutical & Fine Chemical Synthesis

  • Intermediate in the synthesis of heterocyclic pharmaceutical compounds

  • Used in the preparation of biologically active molecules

  • Building block in agrochemical and specialty chemical manufacturing

The presence of both ester and N-oxide groups makes it valuable for multi-step synthetic transformations.

Research & Development

Commonly employed in:

  • Academic organic chemistry research

  • Medicinal chemistry studies

  • Structure–activity relationship (SAR) investigations

  • Development of novel heterocyclic compounds

Its electronic modulation through the N-oxide group provides synthetic versatility.

Safety & Handling

GHS Classification (typical for similar compounds):

  • May be harmful if swallowed

  • May cause skin and eye irritation

  • May cause respiratory irritation

Common Hazard Statements:

  • H302: Harmful if swallowed

  • H315: Causes skin irritation

  • H319: Causes serious eye irritation

  • H335: May cause respiratory irritation

Precautionary Statements:

  • P261: Avoid breathing dust

  • P280: Wear protective gloves and eye protection

  • P305 + P351 + P338: IF IN EYES, rinse cautiously with water and remove contact lenses

  • P301 + P312: IF SWALLOWED, call a doctor if you feel unwell

Handle in a well-ventilated area using appropriate personal protective equipment (PPE).

Practical Details & Supplier Information

Typical Purity: 97–99% (Research and Industrial Grade)

Storage Conditions:

  • Store in a tightly sealed container

  • Keep in a cool, dry, and well-ventilated area

  • Protect from moisture and direct sunlight

  • Keep away from strong oxidizing or reducing agents

Commercial Use:
Available from specialty chemical suppliers for research and industrial synthesis applications.
Not intended for direct pharmaceutical, food, or diagnostic use without proper regulatory compliance.

Summary Statement

14906-37-7 (Ethyl isonicotinate N-oxide) is a pyridine N-oxide derivative widely utilized as a versatile intermediate in heterocyclic and pharmaceutical synthesis. Its combination of ester and N-oxide functional groups enables regioselective modifications and advanced synthetic transformations, making it valuable in research, fine chemical production, and medicinal chemistry development.

As a trusted manufacturer and supplier in Hyderabad, SriniChem provides high-quality 14906-37-7  (Ethyl isonicotinate N-oxide) produced under strict quality control standards. Our product, with CAS No: 14906-37-7 , is suitable for both research and industrial use. Choose SriniChem for reliable supply, technical expertise, and customer-focused service. Contact SriniChem today for 

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