2-Bromo-5-chlorophenol (CAS No. 13659-23-9) is an important halogenated phenolic compound widely used as an intermediate in pharmaceuticals, agrochemicals, dyes, and specialty chemical manufacturing. Known for its balanced reactivity and stability, it plays a key role in advanced organic synthesis and industrial applications that require precise halogen substitution. This article provides a detailed overview of its structure, chemical properties, and its growing significance across industries.
Chemical Name: 2-Bromo-5-chlorophenol
CAS Number: 13659-23-9
Molecular Formula: C₆H₄BrClO
Molecular Weight: Approximately 223.45 g/mol
Functional Groups:
Phenolic hydroxyl group (–OH)
Halogens (bromine and chlorine) positioned at the 2 and 5 locations
This structure results in distinct chemical behavior including enhanced reactivity, improved stability, and suitability for selective substitution reactions.
2-Bromo-5-chlorophenol typically appears as a white to light yellow crystalline solid. Its key characteristics include:
High purity potential for sensitive chemical synthesis
Moderate solubility in organic solvents
Strong aromatic stability due to benzene ring structure
Dual halogen reactivity, enabling targeted molecular transformations
Phenolic functionality, allowing hydrogen bonding and enhanced chemical engagement
These properties make it a valuable building block for complex organic molecules.
2-Bromo-5-chlorophenol serves as an essential intermediate in synthesizing:
Active pharmaceutical ingredients (APIs)
Novel drug candidates
Halogenated aromatic compounds used in medicinal chemistry
Its combination of phenolic and halogen functionalities makes it ideal for multi-step synthesis in pharma R&D and production.
The agrochemical sector uses this compound in the development of:
Herbicides
Pesticides
Fungicides
Plant growth regulators
Its reactivity supports the creation of stable, high-performance crop protection solutions.
2-Bromo-5-chlorophenol is often used as a precursor for manufacturing specialty dyes and pigments, offering:
Better color stability
Enhanced chemical resistance
Improved brightness and durability
Its halogenated structure is particularly valuable in designing high-performance pigments.
In advanced organic chemistry, it contributes to:
Synthesis of aromatic intermediates
Development of functional materials
Custom molecules for research laboratories
Specialty resins and coatings
Its versatility makes it a staple reagent in chemical design and innovation.
The rising demand for complex molecules in pharmaceuticals, advanced materials, and agriculture continues to drive the need for intermediates like 2-Bromo-5-chlorophenol. Key benefits include:
High versatility in multiple industries
Selective reactivity for precise molecular engineering
Chemical stability, ensuring safe storage and transport
Compatibility with various synthesis pathways
As industries push toward more sophisticated formulations, this compound remains a valuable building block.
2-Bromo-5-chlorophenol (CAS 13659-23-9) stands out as a reliable and versatile intermediate widely used across chemical, pharmaceutical, and agricultural sectors. Its distinct structure and functional properties make it indispensable in developing high-value products and driving innovation in modern chemistry. With continuous growth in specialty chemical manufacturing, its relevance is expected to rise even further.
