Compound Overview

• Systematic Name: 1-(4-Fluoropyridin-2-yl)ethanone (also styled as 1-(4-Fluoropyridin-2-yl)ethan-1-one)

• Molecular Formula: C₇H₆FNO
• Molecular Weight: ~139.13 g/mol
• SMILES Notation: CC(C1=NC=CC(F)=C1)=O

Physico-Chemical Properties

• Predicted Boiling Point: Approximately 200.8 °C (±20 °C)

• Predicted Density: ~1.175 g/cm³ (±0.06)
• Calculated LogP: Around 1.42, indicating moderate lipophilicity
• Additional predicted properties such as melting point and exact mass are also reported by Chemsrc and ChemicalBook

Usage & Purity

• Typically available with ≥95–98% purity for research use (laboratory chemicals, building blocks in synthesis)

• Handles and stores under controlled conditions, often at 2–8 °C under an inert atmosphere to preserve integrity

Safety & Handling

According to the Safety Data Sheet (SDS):

• Hazard Classification (OSHA/GHS):

  • Acute Oral Toxicity: Category 4 (harmful if swallowed, H302)

  • Skin Irritation: Category 2 (H315)

  • Serious Eye Irritation: Category 2A (H319)

  • Respiratory Irritation (Single Exposure): Category 3 (H335)

• Signal Word: Warning

• Precautionary Measures:

  • Wear protective gloves, clothing, and eye/face protection (P280).

  • In case of eye contact, rinse cautiously with water for several minutes, remove contact lenses if present, and continue rinsing (P305+P351+P338).

• Additional storage and handling guidelines include avoiding heat, sparks, open flame, moisture, and storing under inert gas to prevent possible reactions or degradation

Summary Description

1-(4-Fluoropyridin-2-yl)ethanone (CAS 1060809-37-1) is a fluorinated pyridine ketone commonly used as a synthetic intermediate in organic and pharmaceutical research. With a molecular formula of C₇H₆FNO and a molar mass of ~139.13 g/mol, it is typically supplied at high purity (≥95–98%) for laboratory use.

It exhibits moderate volatility (boiling ~200 °C) and lipophilicity (log P ~1.4), making it a versatile building block. Users should handle it with care: it is harmful if swallowed, causes skin and serious eye irritation, and may irritate the respiratory tract. Appropriate protective gear and adherence to storage guidelines (cool, inert atmosphere) are essential for safe handling.